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Deshmukh, Ajoy
- Bone Marrow Aspiration and Bone Marrow Biopsy in Hematological Malignancies - A 10 Year Clinicopathological Study
Authors
1 Department of Pathology, Mayo Institute of Medical Sciences, Gadia, Barabanki, Lucknow, Uttar Pradesh, IN
2 Department of Medicine, School of Medical Science and Research, Sharda Hospital, Greater Noida, Uttar Pradesh, IN
3 Department of Pathology, School of Medical Science and Research, Sharda Hospital, Greater Noida, Uttar Pradesh, IN
4 Department of Pathology, Santosh Medical College, Ghaziabad, Uttar Pradesh, IN
Source
International Journal of Contemporary Medicine, Vol 1, No 1 (2013), Pagination: 95-99Abstract
Introduction: Hematological malignancies may derive from either of the two major blood cell lineages- Myeloid and lymphoid cell lines. Lymphoma, lymphocytic leukemias and myeloma are from the lymphoid line, while acute and chronic myelogenous leukemia, myelodysplastic syndromes and myeloproliferative diseases are myeloid in origin.
Objectives : The present study (2002 - 2012) has been aimed to report our bone marrow aspiration and biopsy examination experience with one hundred seven (107) patients of hematological malignancies from North India. and compare the results of bone marrow aspirations with bone marrow biopsy.
Material and Methods: In our study we have included cases of hematological malignancies (Leukemia, Malignant Lymphoma and Multiple Myeloma). In each case serial bone marrow aspiration and biopsy were done before and after chemotherapy and radiotherapy. Aspirate particles, smears, touch imprints of the biopsy core and paraffin sections of the biopsy core were routinely examined.
Results: Out of these one hundred seven (107) cases of hematological malignancies, non-Hodgkin's lymphoma (NHL) were maximum thirty cases (28.03%), followed by chronic myeloid leukemia (CML) twenty cases (18.69%), acute lymphoblastic leukemia (ALL) fifteen cases (14.01%), acute myeloid leukemia (AML) twelve cases (11.21%), multiple myeloma (MM) eleven cases (10.28%), chronic lymphocytic leukemia (CLL) ten cases (09.34%), Hodgkin's lymphoma (HL) eight cases (07.47%) and hairy cell leukemia (HCL) one case (0.93%).
Conclusion: Hematological malignancies were more prevalent in males and more common in first and third decades of life followed by fifth decade In this study bone marrow aspiration was found adequate in hematological malignancies especially in leukemia. Trephine biopsy is essential for diagnosis, when a dry tap or bloody tap occurs as a result of fibrotic or very densely cellular bone marrow. There is virtually no contraindication to aspiration and needle biopsy of the bone marrow. In malignant lymphomas, which are infiltrating to bone marrow, bone marrow biopsy (BMB) was found superior to bone marrow aspiration (BMA) as well as bone marrow involvement is a less favorable prognostic sign than the patients without bone marrow involvement.
Keywords
Bone Marrow, Hematological Malignancies.References
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- Robert W. Mckenna and Jose A. Hernandez (1988): Bone marrow in malignant lymphoma. Hematology/Oncology clinics in North America. 2 (4): 617 – 635.
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- Wolf C. De Peeters (1991): Bone marrow trephine interpretation: Diagnostic utility and potential pitfalls. Histipathology 18: 489 – 483.
- Role of Bone Marrow Study in Malignant Disorders: A Clinicopathological Study of 185 Patients
Authors
1 Department of Pathology, Mayo institute of medical sciences, Gadia, Barabanki, Lucknow, Uttar Pradesh, IN
2 Department of Medicine, School of Medical Science and Research, Greater Noida, Uttar Pradesh, IN
3 Department of Pathology, Dr. B. R. Sur Homeopathic Medical College and Hospital and Research center, New Delhi, IN
4 Department of Pathology, School of Medical Science and Research, Greater Noida, Uttar Pradesh, IN
5 Santosh Medical College, Ghaziabad, Uttar Pradesh, IN
Source
International Journal of Contemporary Medicine, Vol 1, No 2 (2013), Pagination: 36-40Abstract
Introduction: Bone marrow is a reservoir of stem cells and is the site of origin of numerous primary hematological malignancies and is commonly infiltrated by malignant cells in non-hematological malignancies in advanced stages. Objectives: The present study (2002 - 2012) has been aimed to report our experience with one hundred eighty five (185) patients from North India. A comparative study of bone marrow aspiration (BMA) and bone marrow biopsy (BMB) was done simultaneously, where the clinical history was correlated before and after chemotherapy and radiotherapy. Material and Method: In our study we have included cases of malignant disorders (hematological malignancies and non-hematological malignancies). In each case bone marrow aspiration and biopsy were done before and after chemotherapy and radiotherapy. Aspirate particles, smears, touch imprints of the biopsy core and paraffin sections of the biopsy core were routinely examined. Results: In our study we have included cases of hematological malignancies (Leukemia, Multiple Myeloma and Malignant Lymphoma) and non-hematological malignancies (Carcinoma of Breast, Prostate, Lung, Kidney, Urinary bladder, GIT, Thyroid, Round cell tumors and Indeterminate tumors). In hematological malignancies, non-Hodgkin's lymphomas (NHL) were maximum thirty cases (28.03%) and hairy cell leukemia (HCL) one case (0.93%). In non-hematological malignancies or primary tumors, there were maximum cases of breast carcinoma, twenty four cases (30.76%) and minimum two cases of thyroid carcinoma (02.56%). Conclusion: Malignant disorders were more prevalent in males and were seen in all the age groups. In this study bone marrow aspiration was found adequate in hematological malignancies especially in leukemia. Bone marrow biopsy found to be more informative in lymphoma and Metastatic tumors Bone marrow involvement indicated poor prognosis in metastatic tumors except in seven cases (18.42%) of malignant lymphoma. There was no complication of the procedure even in cases of thrombocytopenia.Keywords
Bone Marrow, Hematological Malignancies, Non-Hematological MalignanciesReferences
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- Richard A. Savage, George C. Hoffman and Keren Shaker R.N. (1978): Diagnostic problems involved in detection of metastatic neoplasm of bone marrow aspirates compared with needle biopsy. American J. Clin. Pathol. (70): 623 – 627.
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- Study of Coronary Artery Disease Risk Factors and Value of CRP in Coronary Risk Determination in Semi Urban Population of Western U.P. India
Authors
1 Saraswathi Institute of Medical Sciences, Hapur, U.P., IN
2 Muzaffarnagar Medical College, U.P., IN
3 Saraswathi Institute of Medical Sciences, Hapur, U.P, IN
Source
Indian Journal of Public Health Research & Development, Vol 2, No 1 (2011), Pagination: 1-3Abstract
This study was conducted to identify the factors that increase the risk for coronary artery disease and is an extremely important area in health sciences. A total number of 300 patients (92% males and 8% females) were studied. They were divided into two groups, above 40 yrs and below 40 yrs of age.
In the first group (> 40 yrs.) total number of patients were 240 (80% of total 300 patients) .Among 240 patients males were 216(90 %) and females were 24 (10%). High cholesterol more than 200 mg /dl was present in 55% males and in 50 % females. High triglyceride >150 mg % was present in 50 % males and in 48 % female patients. High LDL was present in 30 % males and 25 % females. Low HDL was present in 50 % males and 45 % females. In second group (<40 yrs), all patients were males. High cholesterol was present in 58 % of cases. high triglyceride in 60 % cases low HDL in 50 %, and high LDL in 45 % . Smoking was present in 30 % cases. Hypertension was present in 35 % cases. Obesity was present in 40 % males and 45 %, females. Central obesity was present in 60 % males and 79 % females.
Association of age, high LDL cholesterol, and hypertension, high triglyceride in males and central obesity in females were recorded with CAD patients.
In the younger patients dyslipidemia was more common. Inflammatory markers such as CRP has limited usefulness in the prediction of CAD events over and above conventional risk factors.
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